Search Articles Directory Papua New Guinea: Inderal

Generic Name: propranolol (Oral route)

proe-PRAN-oh-lol

Oral route(Capsule, Extended Release)

Reports of exacerbation of angina and myocardial infarction have been noted following abrupt discontinuance of propranolol. When discontinuance of propranolol is planned, dosage should be gradually reduced over at least a few weeks, and the patient should be cautioned against interruption or cessation of therapy. If propranolol therapy is interrupted and exacerbation of angina occurs, reinstitution of propranolol and management of angina is advised. Since coronary artery disease may be unrecognized, it may be prudent to follow the above advice in patients considered at risk of having occult atherosclerotic heart disease who are given propranolol for other indications .

Commonly used brand name(s)

In the U.S.

Inderal

Inderal LA

InnoPran XL

Propranolol HCl Intensol

Available Dosage Forms:

Tablet

Capsule, Extended Release

Solution

Therapeutic Class: Cardiovascular Agent

Pharmacologic Class: Beta-Adrenergic Blocker, Nonselective

Uses For Inderal

Propranolol is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Propranolol is also used to treat severe chest pain (angina), migraine headaches, or hypertrophic subaortic stenosis (thickened heart muscle).

This medicine may also be used to treat irregular heartbeats, tremors, or pheochromocytoma (adrenal gland tumor). It may also be used to reduce the risk of death in patients who have heart attacks.

This medicine is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart.

This medicine is available only with your doctor's prescription.

Before Using Inderal

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of propranolol capsules, extended-release capsules, and tablets in the pediatric population. Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of propranolol oral solution in children.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of propranolol in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving propranolol.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Thioridazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Albuterol

Amiodarone

Arformoterol

Bambuterol

Bitolterol

Broxaterol

Bupivacaine

Clenbuterol

Clonidine

Colterol

Diatrizoate

Diltiazem

Dronedarone

Epinephrine

Fenoldopam

Fenoterol

Formoterol

Haloperidol

Hexoprenaline

Indacaterol

Isoetharine

Levalbuterol

Lidocaine

Mefloquine

Mepivacaine

Metaproterenol

Pirbuterol

Prilocaine

Procaterol

Reproterol

Rimiterol

Ritodrine

Salmeterol

Terbutaline

Tretoquinol

Tulobuterol

Verapamil

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acarbose

Aceclofenac

Acemetacin

Acetohexamide

Alclofenac

Alfuzosin

Aluminum Carbonate, Basic

Aluminum Hydroxide

Aluminum Phosphate

Amlodipine

Apazone

Arbutamine

Benfluorex

Benoxaprofen

Bromfenac

Bufexamac

Bunazosin

Calcium Carbonate

Carprofen

Chlorpromazine

Chlorpropamide

Cimetidine

Clometacin

Clonixin

Dexketoprofen

Diclofenac

Diflunisal

Digoxin

Dihydroergotamine

Dihydroxyaluminum Aminoacetate

Dihydroxyaluminum Sodium Carbonate

Dipyrone

Disopyramide

Doxazosin

Droxicam

Ergotamine

Etodolac

Etofenamate

Felbinac

Felodipine

Fenbufen

Fenoprofen

Fentiazac

Flecainide

Floctafenine

Flufenamic Acid

Flurbiprofen

Fluvoxamine

Gliclazide

Glimepiride

Glipizide

Gliquidone

Glyburide

Guar Gum

Guggul

Ibuprofen

Indomethacin

Indoprofen

Insulin

Insulin Aspart, Recombinant

Insulin Glulisine

Insulin Lispro, Recombinant

Isoxicam

Ketoprofen

Ketorolac

Lacidipine

Lercanidipine

Lornoxicam

Magaldrate

Manidipine

Meclofenamate

Mefenamic Acid

Meloxicam

Metformin

Mibefradil

Miglitol

Moxisylyte

Nabumetone

Naproxen

Nicardipine

Nifedipine

Niflumic Acid

Nilvadipine

Nimesulide

Nimodipine

Nisoldipine

Nitrendipine

Oxaprozin

Oxyphenbutazone

Phenoxybenzamine

Phentolamine

Phenylbutazone

Phenylephrine

Piperine

Pirazolac

Piroxicam

Pirprofen

Pranidipine

Prazosin

Propoxyphene

Propyphenazone

Proquazone

Quinidine

Repaglinide

Rifapentine

Rizatriptan

Sertraline

St John's Wort

Sulindac

Suprofen

Tamsulosin

Tenidap

Tenoxicam

Terazosin

Tiaprofenic Acid

Tolazamide

Tolbutamide

Tolmetin

Trimazosin

Troglitazone

Tubocurarine

Urapidil

Zileuton

Zomepirac

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Proper Use of propranolol

This section provides information on the proper use of a number of products that contain propranolol. It may not be specific to Inderal. Please read with care.

Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the long-acting oral capsules whole. Do not chew, crush, or open them.

Propranolol extended-release capsules should be taken at bedtime (10 p.m.). This medicine may be taken with or without food. However, you should take it the same way each time.

Measure the concentrated oral solution, Intensol™ with the dropper that comes with the medicine. You may mix the concentrated solution with water, juice, soda, applesauce, or pudding to make it easier to swallow, then take the mixture right away.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For acute heart attack:
- For oral dosage form (solution):
  - Adults—180 to 240 milligrams (mg) per day, given in divided doses.
  - Children—Dose is based on body weight and must be determined by your doctor.
- For oral dosage form (tablets):
  - Adults—At first, 40 milligrams (mg) three times a day. Your doctor may increase your dose if needed.
  - Children—Use and dose must be determined by your doctor.

For adrenal gland tumor (pheochromocytoma):
- For oral dosage form (solution):
  - Adults—60 milligrams (mg) per day, given in divided doses for 3 days before having surgery. In patients who cannot have surgery, the usual dose is 30 mg per day, given in divided doses.
  - Children—Dose is based on body weight and must be determined by your doctor.
- For oral dosage form (tablets):
  - Adults—60 milligrams (mg) per day, given in divided doses for 3 days before having surgery. In patients who cannot have surgery, the usual dose is 30 mg per day, given in divided doses.
  - Children—Use and dose must be determined by your doctor.

For chest pain (angina):
- For oral dosage form (long-acting oral capsules):
  - Adults—At first, 80 milligrams (mg) once a day. Your doctor may increase your dose if needed.
  - Children—Use and dose must be determined by your doctor.
- For oral dosage form (solution):
  - Adults—80 to 320 milligrams (mg) per day, given in divided doses.
  - Children—Dose is based on body weight and must be determined by your doctor.
- For oral dosage form (tablets):
  - Adults—80 to 320 milligrams (mg) per day, given in divided doses.
  - Children—Use and dose must be determined by your doctor.

For high blood pressure (hypertension):
- For oral dosage form (extended-release capsules):
  - Adults—At first, 80 milligrams (mg) once a day, given at bedtime. Your doctor may increase your dose if needed.
  - Children—Use and dose must be determined by your doctor.
- For oral dosage form (long-acting oral capsules):
  - Adults—At first, 80 milligrams (mg) once a day. Your doctor may increase your dose if needed.
  - Children—Use and dose must be determined by your doctor.
- For oral dosage form (solution):
  - Adults—At first, 40 milligrams (mg) two times a day. Your doctor may increase your dose if needed.
  - Children—Dose is based on body weight and must be determined by your doctor.
- For oral dosage form (tablets):
  - Adults—At first, 40 milligrams (mg) two times a day. Your doctor may increase your dose if needed.
  - Children—Use and dose must be determined by your doctor.

For hypertrophic subaortic stenosis (thickened heart muscle):
- For oral dosage form (long-acting oral capsules):
  - Adults—80 to 160 milligrams (mg) once a day.
  - Children—Use and dose must be determined by your doctor.
- For oral dosage form (solution):
  - Adults—20 to 40 milligrams (mg) three or four times a day, given before meals and at bedtime.
  - Children—Dose is based on body weight and must be determined by your doctor.
- For oral dosage form (tablets):
  - Adults—20 to 40 milligrams (mg) three or four times a day, given before meals and at bedtime.
  - Children—Use and dose must be determined by your doctor.

For irregular heartbeats:
- For oral dosage form (solution):
  - Adults—10 to 30 milligrams (mg) three or four times a day, given before meals and at bedtime.
  - Children—Dose is based on body weight and must be determined by your doctor.
- For oral dosage form (tablets):
  - Adults—10 to 30 milligrams (mg) three or four times a day, given before meals and at bedtime.
  - Children—Use and dose must be determined by your doctor.

For migraine headaches:
- For oral dosage form (long-acting oral capsules):
  - Adults—At first, 80 milligrams (mg) once a day. Your doctor may increase your dose if needed.
  - Children—Use and dose must be determined by your doctor.
- For oral dosage form (solution):
  - Adults—At first, 80 milligrams (mg) per day, given in divided doses. Your doctor may increase your dose if needed.
  - Children—Dose is based on body weight and must be determined by your doctor.
- For oral dosage form (tablets):
  - Adults—At first, 80 milligrams (mg) per day, given in divided doses. Your doctor may increase your dose if needed.
  - Children—Use and dose must be determined by your doctor.

For tremors:
- For oral dosage form (solution):
  - Adults—At first, 40 milligrams (mg) two times a day. Your doctor may increase your dose if needed.
  - Children—Dose is based on body weight and must be determined by your doctor.
- For oral dosage form (tablets):
  - Adults—At first, 40 milligrams (mg) two times a day. Your doctor may increase your dose if needed.
  - Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Inderal

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects. .

Propranolol may cause heart failure in some patients. Check with your doctor right away if you are having chest pain or discomfort; dilated neck veins; extreme fatigue; irregular breathing; an irregular heartbeat; shortness of breath; swelling of the face, fingers, feet, or lower legs; weight gain; or wheezing.

This medicine may cause changes in your blood sugar levels. Also, this medicine may cover up signs of low blood sugar, such as a rapid pulse rate. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests.

Make sure any doctor or dentist who treats you knows that you are using this medicine. Do not stop taking this medicine before surgery without your doctor's approval.

This medicine may cause some people to become less alert than they are normally. If this side effect occurs, do not drive, use machines, or do anything else that could be dangerous if you are not alert while taking propranolol.

Do not interrupt or stop taking this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping it completely. Some conditions may become worse when the medicine is stopped suddenly, which can be dangerous.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth while you are using this medicine.

Serious skin reactions can occur during treatment with this medicine. Check with your doctor right away if you have any of the following symptoms while taking this medicine: blistering, peeling, or loosening of the skin; chills; cough; diarrhea; fever; itching; joint or muscle pain; red skin lesions; sore throat; sores, ulcers, or white spots in your mouth or lips; or unusual tiredness or weakness.

Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

Propranolol will add to the effects of alcohol and other central nervous system (CNS) depressants. CNS depressants are medicines that slow down the nervous system and may cause drowsiness. Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates or medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Inderal Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Abdominal or stomach pain and tenderness

black, tarry stools

blistering, peeling, or loosening of the skin

blood in the urine

bloody nose

bloody stools

blurred or loss of vision

body aches or pain

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain or discomfort

confusion about identity, place, and time

congestion

constipation

cough

cracks in the skin

crying

decreased awareness or responsiveness

decreased urine output

depersonalization

diarrhea

difficulty with breathing or swallowing

difficulty with swallowing

dilated neck veins

disturbed color perception

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

double vision

dryness or soreness of the throat

dysphoria

euphoria

extreme fatigue

fast, pounding, slow, or irregular heartbeat

fever and chills

general feeling of discomfort, illness, or weakness

hair loss

halos around lights

headaches

heavier menstrual periods

hives

hoarseness

irregular breathing

itching

lightheadedness, dizziness, or fainting

loss of heat from the body

mental depression

mimicry of speech or movements

muscle or joint pain

mutism

nausea

negativism

night blindness

noisy breathing

overbright appearance of lights

paleness or cold feeling in the fingertips and toes

paranoia

peculiar postures or movements, mannerisms, or grimacing

pinpoint red or purple spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

quick to react or overreact emotionally

rapidly changing moods

rectal bleeding

red skin lesions, often with a purple center

red, irritated eyes

red, swollen skin

reddening of the skin, especially around the ears

runny nose

scaly skin

seeing, hearing, or feeling things that are not there

severe sleepiness

short-term memory loss

shortness of breath

skin irritation or rash, including rash that looks like psoriasis

skin rash

sores, ulcers, or white spots in the mouth or on the lips

sweating

swelling of the eyes, face, fingers, feet, or lower legs

swollen glands

tender, swollen glands in the neck

tightness in the chest

tingling or pain in fingers or toes when exposed to cold

trouble with swallowing

troubled breathing

tunnel vision

unusual bleeding or bruising

unusual tiredness or weakness

voice changes

vomiting

weight gain

wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Dry eyes

heartburn

loss of strength or energy

muscle weakness

pain or discomfort in the chest, upper stomach, or throat

sleeplessness

stomach cramps

trouble sleeping

unable to sleep

unusual drowsiness, dullness, or feeling of sluggishness

vivid dreams

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Inderal side effects (in more detail)

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More Inderal resources

Inderal Side Effects (in more detail)
Inderal Use in Pregnancy & Breastfeeding
Drug Images
Inderal Drug Interactions
Inderal Support Group
32 Reviews for Inderal - Add your own review/rating

Inderal Prescribing Information (FDA)

Inderal MedFacts Consumer Leaflet (Wolters Kluwer)

Inderal Consumer Overview

Propranolol Prescribing Information (FDA)

Propranolol MedFacts Consumer Leaflet (Wolters Kluwer)

Inderal LA Sustained-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)

Inderal LA Prescribing Information (FDA)

InnoPran XL Sustained-Release Bead Capsules MedFacts Consumer Leaflet (Wolters Kluwer)

InnoPran XL Prescribing Information (FDA)

Propranolol Hydrochloride Monograph (AHFS DI)

Compare Inderal with other medications

Angina
Aortic Stenosis
Arrhythmia
Benign Essential Tremor
Heart Attack
Hemangioma
High Blood Pressure
Migraine Prevention
Mitral Valve Prolapse
Performance Anxiety
Pheochromocytoma
Thyrotoxicosis

Search Articles Directory Papua New Guinea

Wednesday, October 26, 2016

Inderal