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Thursday, October 27, 2016

Iprivask

Generic Name: desirudin (deh sih rue din)

Brand Names: Iprivask

What is Iprivask (desirudin)?

Desirudin is an anticoagulant (blood thinner). Desirudin prevents the formation of blood clots.

Desirudin is used to prevent deep vein thrombosis (a type of blood clot), which may lead to pulmonary embolism (blood clot in the lung), in patients undergoing hip replacement surgery.

Desirudin may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Iprivask (desirudin)?

There is a risk of bleeding in the spinal or epidural space, possibly resulting in paralysis, when desirudin is used along with spinal or epidural anesthesia or spinal puncture. This risk may be increased by the use of indwelling epidural catheters or by the concomitant use of drugs that affect blood clotting.

Desirudin is intended for subcutaneous (into the fat) injection. Do not inject this medication intramuscularly (into the muscle) or intravenously (into the vein). Do not take aspirin, ibuprofen (Motrin, Advil, Nuprin, and others), ketoprofen (Orudis KT, Orudis, Oruvail), naproxen (Aleve, Naprosyn, Anaprox, and others), indomethacin (Indocin), or any other nonsteroidal anti-inflammatory medication without first talking to your doctor. These medicines may lead to bleeding when taken with desirudin. Ask your pharmacist or doctor before taking any prescription or over-the-counter medication while taking desirudin.

What should I discuss with my healthcare provider before using Iprivask (desirudin)?

Do not use desirudin if you

have an irreversible coagulation disorder;

have uncontrolled active bleeding;

have an allergy to desirudin or other blood thinners; or

cannot have accurate blood testing done prior to and during dosing.

Before using desirudin, tell your doctor if you

have bacterial endocarditis;

have high blood pressure that is not being controlled;

need to have or have recently had surgery, a biopsy, or another invasive procedure;

have a history of stroke or bleeding in the brain;

have a history of bleeding in the eyes (hemorrhagic retinopathy);

have eye problems due to diabetes (diabetic retinopathy);

have hemophilia or another blood disorder;

have a stomach ulcer;

have liver disease; or

have kidney disease.

You may not be able to use desirudin, or you may require a dosage adjustment or special monitoring during therapy if you have any of the conditions listed above.

Desirudin is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn baby. Do not use desirudin without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether desirudin passes into breast milk. Do not use this medication without first talking to your doctor if you are breast-feeding a baby.

How should I use Iprivask (desirudin)?

Desirudin will probably be administered by a healthcare professional. If you are using desirudin at home, administer the medication exactly as directed by your doctor. If you do not understand these directions, ask your doctor, nurse, or pharmacist to explain them to you.

Desirudin is intended for subcutaneous (into the fat) injection. Do not inject this medication intramuscularly (into the muscle) or intravenously (into the vein). Do not mix desirudin with other injections or infusions.

If you are using the medication at home, your doctor or nurse will give you detailed instructions on how to inject desirudin. It should be injected into the fat of the stomach or the upper thighs. Follow your doctor's instructions.

Sit or lie down before receiving an injection. Lift a fold of skin and insert the needle completely into the fold. The whole length of the needle should be introduced into the skin fold and the skin fold should be held throughout the injection. To lessen bruising, do not rub the area after injecting the medication. Rotate the injection sites as directed by your doctor.

Do not use any vial of desirudin that is discolored or that has particles in it. Do not stop using this medication without first talking to your doctor.

It is important to use desirudin regularly to get the most benefit.

Your doctor may want you to have blood tests or other medical evaluations during treatment with desirudin to monitor progress and side effects.

Store desirudin at room temperature away from moisture and heat. After mixing the solution for injection, it can be stored for up to 24 hours at room temperature. Any unused medication should be discarded after 24 hours.

What happens if I miss a dose?

Contact your doctor if you miss a dose of desirudin.

What happens if I overdose?

Seek emergency medical attention if an overdose of desirudin is suspected.

Symptoms of an overdose may include unusual bleeding from wounds or injection sites; nosebleeds; black, bloody, or tarry stools; blood in the urine; and easy bruising or bleeding.

What should I avoid while using Iprivask (desirudin)?

Do not take aspirin, ibuprofen (Motrin, Advil, Nuprin, and others), ketoprofen (Orudis KT, Orudis, Oruvail), naproxen (Aleve, Naprosyn, Anaprox, and others), indomethacin (Indocin), or any other nonsteroidal anti-inflammatory medication without first talking to your doctor. These medicines may lead to bleeding when taken with desirudin. Ask your pharmacist or doctor before taking any prescription or over-the-counter medication while taking desirudin.

Iprivask (desirudin) side effects

If you experience any of the following serious side effects, stop using desirudin, and seek emergency medical attention or contact your doctor immediately:

an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

any prolonged or unexplained bleeding;

pain, warmth, or redness in an arm or leg, or difficulty breathing, which could indicate a blood clot; or

ulceration at the injection site.

Other less serious side effects may be more likely to occur. Continue to use desirudin and notify your doctor if you experience

mild pain, redness, or warmth at the injection site;

anemia (low level of red blood cells detected by blood tests); or

nausea.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Iprivask (desirudin)?

Do not use desirudin with any of the following medicines without first talking to your doctor:

aspirin,

ibuprofen (Motrin, Advil, Nuprin, and others), ketoprofen (Orudis KT, Orudis, Oruvail), naproxen (Aleve, Naprosyn, Anaprox, and others), indomethacin (Indocin), diclofenac (Cataflam, Voltaren), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), ketorolac (Toradol), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), tolmetin (Tolectin), or any other nonsteroidal anti-inflammatory medication;

dalteparin (Fragmin), danaparoid (Orgaran), enoxaparin (Lovenox), tinzaparin (Innohep);

warfarin (Coumadin);

aspirin and dipyridamole (Aggrenox);

ticlopidine (Ticlid) or clopidogrel (Plavix); or

dipyridamole (Persantine).

The drugs listed above may increase the effects of desirudin, which could become dangerous. You may not be able to take desirudin, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with desirudin. Talk to your doctor and pharmacist before using any prescription or over-the-counter medicines, including herbal products.

More Iprivask resources

Iprivask Side Effects (in more detail)
Iprivask Use in Pregnancy & Breastfeeding
Iprivask Drug Interactions
Iprivask Support Group
0 Reviews for Iprivask - Add your own review/rating

Iprivask Prescribing Information (FDA)

Iprivask MedFacts Consumer Leaflet (Wolters Kluwer)

Iprivask Monograph (AHFS DI)

Iprivask Advanced Consumer (Micromedex) - Includes Dosage Information

Desirudin Professional Patient Advice (Wolters Kluwer)

Compare Iprivask with other medications

Deep Vein Thrombosis, Prophylaxis

Where can I get more information?

Your pharmacist has additional information about desirudin written for health professionals that you may read.

What does my medication look like?

Desirudin is available with a prescription under the brand name Iprivask. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

See also: Iprivask side effects (in more detail)

Imitrex Tablets

Pronunciation: SOO-ma-TRIP-tan
Generic Name: Sumatriptan
Brand Name: Imitrex

Imitrex is used for:

The treatment of migraine headaches with or without aura (eg, flashing lights, wavy lines, dark spots). It may also be used for other conditions as determined by your doctor.

Imitrex is a serotonin 5-HT ₁ receptor agonist ("triptan"). It works by narrowing blood vessels in the brain, which helps to relieve migraines.

Do NOT use Imitrex if:

you are allergic to any ingredient in Imitrex

you have a history of ischemic heart disease (eg, angina, heart attack), coronary artery disease (CAD), other moderate to severe heart problems, brain blood vessel disease (eg, stroke, transient ischemic attack), or other blood vessel disease (eg, Raynaud syndrome, ischemic bowel disease)

you have uncontrolled high blood pressure or severe liver problems

you have certain types of migraines (eg, hemiplegic, basilar)

you are taking or have taken a monamine oxidase inhibitor (MAOI) (eg, phenelzine) within the past 14 days

you have used certain other migraine medicines within the past 24 hours (eg, an ergot derivative [eg, dihydroergotamine, methysergide], another serotonin 5-HT ₁ receptor agonist [eg, eletriptan, rizatriptan])

you are taking sibutramine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Imitrex:

Some medical conditions may interact with Imitrex. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have history of liver or kidney problems, seizures (eg epilepsy), heart problems, or other types of headaches (eg, cluster headaches)

if you have shortness of breath, chest pain, or a history of high blood pressure, heart attack, stroke, high cholesterol, diabetes, or smoking

if you are a woman who is past menopause

if you are a man who is more than 40 years old

if you are very overweight

if a family member has had heart disease or a stroke

Some MEDICINES MAY INTERACT with Imitrex. Tell your health care provider if you are taking any other medicines, especially any of the following:

Selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), serotonin norepinephrine reuptake inhibitors (SNRIs) (eg, duloxetine), orsibutramine because the risk of a serious side effect called serotonin syndrome may be increased. Symptoms of serotonin syndrome may include mental or mood changes, hallucinations, fast heartbeat, fever, loss of coordination, muscle spasms, increased sweating, nausea, vomiting, or diarrhea

MAOIs (eg, phenelzine) because they may increase the risk of Imitrex's side effects

Ergot derivatives (eg, dihydroergotamine, methysergide) or other serotonin 5-HT ₁ receptor agonists (eg, eletriptan, rizatriptan) because the risk of their side effects may be increased by Imitrex

This may not be a complete list of all interactions that may occur. Ask your health care provider if Imitrex may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Imitrex:

Use Imitrex as directed by your doctor. Check the label on the medicine for exact dosing instructions.

An extra patient leaflet is available with Imitrex. Talk to your pharmacist if you have questions about this information.

Take Imitrex by mouth with or without food.

Swallow Imitrex whole. Do not break, crush, or chew before swallowing.

It is best to take a dose of Imitrex as soon as you notice symptoms of a migraine attack.

If your migraine symptoms go away and then come back, or if you have a partial response to the first dose, you may take a second dose as directed by your doctor. Wait at least 2 hours between doses.

If your symptoms do not improve after the first dose, do not take a second dose for the same attack. Contact your doctor.

Do not take more than the amount prescribed by your doctor in a 24-hour period or treat more than 4 headaches within 30 days without checking with your doctor.

If you miss a dose of Imitrex and you still have a headache, follow your doctor's dosing instructions. Contact your doctor immediately if you are unsure of what to do if you miss a dose. Do not take Imitrex more often than prescribed. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Imitrex.

Important safety information:

Imitrex may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Imitrex with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Overuse of Imitrex can cause your headache to become worse. Do NOT take more than the recommended dose or use more often than prescribed without checking with your doctor.

Rarely, serious heart problems (eg, heart attack, irregular heartbeat) have been reported within a few hours of using Imitrex. Contact your doctor at once if fast or irregular heartbeat; chest, jaw, or neck pain or numbness; numbness of an arm or leg; severe stomach pain, dizziness, or vomiting; fainting; or vision changes occur. Discuss any questions or concerns with your doctor.

Serotonin syndrome is a possibly fatal syndrome that can be caused by Imitrex. Your risk may be greater if you take Imitrex with certain other medicines (eg, SSRIs, SNRIs). Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.

Imitrex should not be used to prevent or reduce the number of migraine headaches you have. If you have a headache that is different than your usual migraine headaches, check with your doctor before using Imitrex.

Lab tests, including heart function tests, may be performed while you use Imitrex. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Imitrex should not be used in the ELDERLY; the risk of serious side effects (eg, heart problems, high blood pressure) may be increased.

Imitrex should not be used in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.

PREGNANCY and BREAST-FEEDING: It is not known if Imitrex can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Imitrex while you are pregnant. Imitrex is found in breast milk. If you are or will be breast-feeding while you use Imitrex, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Imitrex:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Burning; dizziness; drowsiness; feeling of heaviness or pressure; muscle aches; numbness or tingling of the skin; sick feeling; tingling; tiredness; warm/hot sensation.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody diarrhea; chest pain; confusion; fainting; fast or irregular heartbeat; fever; hallucination; hearing problems; numbness or tingling of an arm or leg; one-sided weakness; pain, tightness, or pressure in the jaw, neck, or chest; seizures; severe headache, dizziness, or vomiting; severe or prolonged flushing; severe stomach pain; shortness of breath; speech changes; very cold or blue fingers or toes; vision changes or loss of vision; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Imitrex side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blue skin or lips; chest pain; dilated pupils; loss of coordination; paralysis; redness of the fingers or toes; seizures; slow or difficult breathing; tremor.

Proper storage of Imitrex:

Store Imitrex between 36 and 86 degrees F (2 and 30 degrees C). Store away from heat, moisture, and light. Do not freeze. Do not store at temperatures above 86 degrees F (30 degrees C). Do not store in the bathroom. Keep Imitrex in the case provided. Throw away expired medicine as directed by your doctor (the expiration date is printed on the treatment pack). Keep Imitrex out of the reach of children and away from pets.

General information:

If you have any questions about Imitrex, please talk with your doctor, pharmacist, or other health care provider.

Imitrex is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is summary only. It does not contain all information about Imitrex. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Imitrex resources

Imitrex Side Effects (in more detail)
Imitrex Dosage
Imitrex Use in Pregnancy & Breastfeeding
Drug Images
Imitrex Drug Interactions
Imitrex Support Group
61 Reviews for Imitrex - Add your own review/rating

Compare Imitrex with other medications

Cluster Headaches
Cyclic Vomiting Syndrome
Migraine
New Daily Persistent Headache

Insulin Isophane (NPH)/Insulin Regular Pens

Pronunciation: IN-su-lin EYE-soe-fane
Generic Name: Insulin Isophane (NPH)/Insulin Regular
Brand Name: Examples include Humulin 50/50 and Novolin 70/30

Insulin Isophane (NPH)/Insulin Regular Pens are used for:

Treating diabetes mellitus.

Insulin Isophane (NPH)/Insulin Regular Pens are a combination of an intermediate-acting and a fast-acting form of the hormone insulin. It works by helping your body to use sugar properly. This lowers the amount of glucose in the blood, which helps to treat diabetes.

Do NOT use Insulin Isophane (NPH)/Insulin Regular Pens if:

you are allergic to any ingredient in Insulin Isophane (NPH)/Insulin Regular Pens

you are having an episode of low blood sugar

Contact your doctor or health care provider right away if any of these apply to you.

Before using Insulin Isophane (NPH)/Insulin Regular Pens:

Some medical conditions may interact with Insulin Isophane (NPH)/Insulin Regular Pens. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you drink alcoholic beverages or smoke

if you have kidney or liver problems; nerve problems; adrenal, pituitary, or thyroid problems; or diabetic ketoacidosis

if you use 3 or more insulin injections per day

if you are fasting, have high blood sodium levels, or are on a low-salt (sodium) diet

Some MEDICINES MAY INTERACT with Insulin Isophane (NPH)/Insulin Regular Pens. Tell your health care provider if you are taking any other medicines, especially any of the following:

Beta-blockers (eg, propranolol), clonidine, guanethidine, lithium, or reserpine because they may increase the risk of high or low blood sugar, or may hide the signs and symptoms of low blood sugar, if it occurs

Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), disopyramide, fenfluramine, fibrates (eg, clofibrate, gemfibrozil), fluoxetine, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), oral medicines for diabetes (eg, glipizide, metformin, nateglinide), pentamidine, propoxyphene, salicylates (eg, aspirin), somatostatin analogs (eg, octreotide), or sulfonamide antibiotics (eg, sulfamethoxazole) because the risk of low blood sugar may be increased

Corticosteroids (eg, prednisone), danazol, diuretics (eg, furosemide, hydrochlorothiazide), estrogen, hormonal contraceptives (eg, birth control pills), isoniazid, niacin, phenothiazines (eg, chlorpromazine), progesterones (eg, medroxyprogesterone), somatropin, sympathomimetics (eg, albuterol, epinephrine, terbutaline), or thyroid hormones (eg, levothyroxine) because they may decrease Insulin Isophane (NPH)/Insulin Regular Pens's effectiveness, resulting in high blood sugar

This may not be a complete list of all interactions that may occur. Ask your health care provider if Insulin Isophane (NPH)/Insulin Regular Pens may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Insulin Isophane (NPH)/Insulin Regular Pens:

Use Insulin Isophane (NPH)/Insulin Regular Pens as directed by your doctor. Check the label on the medicine for exact dosing instructions.

An extra patient leaflet is available with Insulin Isophane (NPH)/Insulin Regular Pens. Talk to your pharmacist if you have questions about this information.

Use Insulin Isophane (NPH)/Insulin Regular Pens within 30 to 60 minutes before a meal, as directed by your doctor.

If you will be using Insulin Isophane (NPH)/Insulin Regular Pens at home, a health care provider will teach you how to use it. Be sure you understand how to use it. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.

Carefully rotate the vial or container as directed before each injection. This will ensure that the contents are evenly mixed. This insulin should look uniformly cloudy or milky.

Do not use Insulin Isophane (NPH)/Insulin Regular Pens if it contains particles or clumps, is discolored, or if the vial or container is cracked or damaged.

Do NOT dilute Insulin Isophane (NPH)/Insulin Regular Pens or mix it with other insulin. Do NOT use Insulin Isophane (NPH)/Insulin Regular Pens in an insulin pump.

Use the proper technique taught to you by your doctor. Inject deep under the skin, NOT into a vein or muscle.

Injection sites within an injection area (abdomen, thigh, upper arm) must be rotated from one injection to the next.

Be sure you have purchased the correct insulin. Insulin comes in a variety of containers, including vials, cartridges, and pens. Make sure that you understand how to properly measure and prepare your dose. If you have any questions about measuring and preparing your dose, contact your doctor or pharmacist for information.

Insulin Isophane (NPH)/Insulin Regular Pens begins lowering blood sugar within 30 to 60 minutes after an injection. The effect may last for up to 24 hours.

Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.

It is very important to follow your insulin regimen exactly. Do NOT miss any doses. Ask your doctor for specific instructions to follow in case you ever miss a dose of insulin.

Ask your health care provider any questions you may have about how to use Insulin Isophane (NPH)/Insulin Regular Pens.

Important safety information:

Insulin Isophane (NPH)/Insulin Regular Pens may cause drowsiness, dizziness, lightheadedness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Insulin Isophane (NPH)/Insulin Regular Pens with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Do not drink alcohol without discussing it with your doctor. Drinking alcohol may increase the risk of developing high or low blood sugar.

Do NOT take more than the recommended dose, use Insulin Isophane (NPH)/Insulin Regular Pens more often than prescribed, or change the type or dose of insulin you are using without checking with your doctor.

Any change of insulin should be made cautiously and only under medical supervision. Changes in purity, strength, brand (manufacturer), type (regular, NPH, lente), species (beef, pork, beef-pork, human), and/or method of manufacture may require a change in dose.

Illness, especially with nausea and vomiting, may cause your insulin requirements to change. Even if you are not eating, you still require insulin. You and your doctor should establish a sick day plan to use in case of illness. When you are sick, test your blood/urine frequently and call your doctor as instructed.

Tell your doctor or dentist that you take Insulin Isophane (NPH)/Insulin Regular Pens before you receive any medical or dental care, emergency care, or surgery.

If you will be traveling across time zones, consult your doctor concerning adjustments in your insulin schedule.

Carry an ID card at all times that says you have diabetes.

An insulin reaction resulting from low blood sugar levels (hypoglycemia) may occur if you take too much insulin, skip a meal, or exercise too much. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you more hungry. It is a good idea to carry a reliable source of glucose (eg, tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar levels quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.

Developing a fever or infection, eating significantly more than prescribed, or missing your dose of insulin may cause high blood sugar (hyperglycemia). High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell you doctor right away.

Check with your doctor if you notice a depression in the skin or skin thickening at the injection site. You may need to change your injection technique.

Proper diet, regular exercise, and regular testing of blood sugar are important for best results when using Insulin Isophane (NPH)/Insulin Regular Pens.

Lab tests, including fasting blood glucose levels and hemoglobin A_1c, may be performed while you use Insulin Isophane (NPH)/Insulin Regular Pens. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Insulin Isophane (NPH)/Insulin Regular Pens with caution in the ELDERLY; if low blood sugar occurs, it may be more difficult to recognize in these patients.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Insulin Isophane (NPH)/Insulin Regular Pens while you are pregnant. It is not known if Insulin Isophane (NPH)/Insulin Regular Pens are found in breast milk. If you are or will be breast-feeding while you use Insulin Isophane (NPH)/Insulin Regular Pens, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Insulin Isophane (NPH)/Insulin Regular Pens:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Redness, swelling, itching, or mild pain at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; wheezing; muscle pain); changes in vision; chills; confusion; dizziness; drowsiness; fainting; fast or irregular heartbeat; headache; loss of consciousness; mood changes; seizures; slurred speech; swelling; tremor; trouble breathing; trouble concentrating; unusual hunger; unusual sweating; weakness.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include chills; dizziness; drowsiness; fainting; fast or irregular heartbeat; headache; loss of consciousness; nervousness; seizures; shakiness; sweating; tremor; vision changes; weakness.

Proper storage of Insulin Isophane (NPH)/Insulin Regular Pens:

VIALS: Store new (unopened) vials in the refrigerator between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Certain brands of Insulin Isophane (NPH)/Insulin Regular Pens may be stored at room temperature, below 77 degrees F (25 degrees C), for up to 6 weeks (42 days), if refrigeration is not possible. Check with your pharmacist to see if your brand can be stored at room temperature. Keep Insulin Isophane (NPH)/Insulin Regular Pens in the carton to protect from light.

Store used (open) vials as directed in the extra patient leaflet or by your health care provider. Check with your pharmacist to see how long unrefrigerated or opened vials may be used. Store away from heat and light. If Insulin Isophane (NPH)/Insulin Regular Pens has been frozen or overheated, throw it away.

INNOLETS, PENS, and PENFILL CARTRIDGES: Store new (unopened) InnoLets, Pens, or PenFills in a refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Store used (open) InnoLets, Pens, or PenFill cartridges at room temperature, below 86 degrees F (30 degrees C). Do NOT store used (open) InnoLets, Pens, or PenFills in the refrigerator. Store away from heat and light. If Insulin Isophane (NPH)/Insulin Regular Pens has been frozen or overheated, throw it away. Throw away unrefrigerated or used InnoLets, Pens, or PenFills after 10 days, even if they still contain medicine.

Do not leave Insulin Isophane (NPH)/Insulin Regular Pens in a car on a warm or sunny day. Do not use Insulin Isophane (NPH)/Insulin Regular Pens after the expiration date stamped on the label. Keep Insulin Isophane (NPH)/Insulin Regular Pens, as well as syringes and needles, out of the reach of children and away from pets.

General information:

If you have any questions about Insulin Isophane (NPH)/Insulin Regular Pens, please talk with your doctor, pharmacist, or other health care provider.

Insulin Isophane (NPH)/Insulin Regular Pens are to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Insulin Isophane (NPH)/Insulin Regular Pens. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Insulin Isophane (NPH)/Insulin Regular resources

Insulin Isophane (NPH)/Insulin Regular Use in Pregnancy & Breastfeeding
Insulin Isophane (NPH)/Insulin Regular Drug Interactions
Insulin Isophane (NPH)/Insulin Regular Support Group
2 Reviews for Insulin Isophane (NPH)/Insulin Regular - Add your own review/rating

Compare Insulin Isophane (NPH)/Insulin Regular with other medications

Diabetes, Type 1
Diabetes, Type 2
Gestational Diabetes

insulin lispro, recombinant Subcutaneous

IN-su-lin LIS-pro, ree-KOM-bi-nant

Commonly used brand name(s)

In the U.S.

Humalog

Lispro-PFC

Available Dosage Forms:

Suspension

Therapeutic Class: Antidiabetic

Pharmacologic Class: Insulin, Ultra Rapid Acting

Uses For insulin lispro, recombinant

Insulin lispro is a fast-acting type of insulin. Insulin is one of many hormones that help the body turn the food we eat into energy. This is done by using the glucose (sugar) in the blood as quick energy. Also, insulin helps us store energy that we can use later. When you have diabetes mellitus (sugar diabetes), your body cannot make enough or does not use insulin properly. So, you must take additional insulin to regulate your blood sugar and keep your body healthy. This is very important as too much sugar in your blood can be harmful to your health.

Insulin lispro starts to work faster than some other types of insulin, and its effects do not last as long. It should act more like the insulin your body would normally produce. Because the effects of insulin lispro are short-acting, your doctor may also prescribe a longer-acting insulin for you to use.

insulin lispro, recombinant is available only with your doctor's prescription.

Before Using insulin lispro, recombinant

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For insulin lispro, recombinant, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to insulin lispro, recombinant or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of insulin lispro in children 3 years of age and older. However, safety and efficacy of insulin lispro have not been established in children younger than 3 years of age.

Geriatric

Although appropriate studies on the relationship of age to the effects of insulin lispro have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of insulin lispro, recombinant in the elderly.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking insulin lispro, recombinant, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using insulin lispro, recombinant with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Alatrofloxacin

Balofloxacin

Ciprofloxacin

Clinafloxacin

Enoxacin

Fleroxacin

Flumequine

Gatifloxacin

Gemifloxacin

Grepafloxacin

Levofloxacin

Lomefloxacin

Moxifloxacin

Norfloxacin

Ofloxacin

Pefloxacin

Prulifloxacin

Rufloxacin

Sparfloxacin

Temafloxacin

Tosufloxacin

Trovafloxacin Mesylate

Using insulin lispro, recombinant with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acebutolol

Alprenolol

Atenolol

Betaxolol

Bevantolol

Bisoprolol

Bitter Melon

Bucindolol

Carteolol

Carvedilol

Celiprolol

Clorgyline

Dilevalol

Esmolol

Fenugreek

Glucomannan

Guar Gum

Iproniazid

Isocarboxazid

Labetalol

Levobunolol

Mepindolol

Metipranolol

Metoprolol

Moclobemide

Nadolol

Nebivolol

Nialamide

Oxprenolol

Pargyline

Penbutolol

Phenelzine

Pindolol

Procarbazine

Propranolol

Psyllium

Selegiline

Sotalol

Talinolol

Tertatolol

Timolol

Toloxatone

Tranylcypromine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Proper Use of insulin lispro, recombinant

Each package of insulin lispro contains a patient information leaflet. Read this leaflet carefully and make sure you understand:

How to prepare the medicine.

How to inject the medicine.

How to use disposable insulin delivery device.

How to use external insulin pump.

How and when to change the infusion set, cartridge adapter, and insulin in the external insulin pump reservoir.

How and when to change the insulin lispro 3-mL cartridge.

How to dispose of syringes, needles, and injection devices.

It is best to use a different place on the body for each injection (e.g., under the skin of your abdomen or stomach, thigh, buttocks, or upper arm). If you have questions about this, contact a member of your health care team.

When used as a mealtime insulin, it should be taken within 15 minutes before a meal or immediately after a meal.

The insulin solution should look clear and colorless. Do not use insulin lispro if it is cloudy or thickened.

When used in an insulin pump: Carefully read and follow the external insulin pump instructions. This insulin should not be mixed with any other insulin or diluted when used in an insulin pump. The insulin lispro in the pump should be changed at least every 7 days and the infusion set and insertion site changed at least every 3 days. If you do not understand how you are to use the insulin pump or have concerns, contact your doctor or pharmacist.

Follow carefully the special meal plan your doctor gave you. This is the most important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed.

Do not change the brand, type, or dose of your insulin unless your doctor tells you to. When you receive a new supply of insulin, check the label to be sure if it is the correct type of insulin.

Dosing

The dose of insulin lispro, recombinant will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of insulin lispro, recombinant. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For injection dosage form:
- For diabetes mellitus:
  - Adults, teenagers, and children 3 years of age and older—The dose is based on your blood sugar and must be determined by your doctor.
  - Children younger than 3 years of age—Use and dose must be determined by your doctor.

Missed Dose

Call your doctor or pharmacist for instructions.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store unused vials, pens, or cartridges in the refrigerator. Do not freeze. The expiration date on the insulin package tells you how long you can keep the medicine in the refrigerator. Throw the medicine away after the expiration date has passed.

The vial that you are currently using may be kept in the refrigerator or at room temperature in a cool place, away from direct heat and light, for only 28 days.

The cartridge or pen that you are currently using should not be refrigerated. You should store the cartridge or pen at room temperature in a cool place, away from direct heat and light, for only 28 days.

Precautions While Using insulin lispro, recombinant

Never share insulin pens or cartridges with others under any circumstances. It is not safe for one pen to be used for more than one person. Sharing needles or pens can result in transmission of hepatitis viruses, HIV, or other blood-borne illnesses.

Your doctor will want to check your progress at regular visits, especially during the first few weeks you take insulin lispro, recombinant. Blood tests may be needed to check for unwanted effects.

It is very important to follow carefully any instructions from your health care team about:

Alcohol—Drinking alcohol may cause severe low blood sugar. Discuss this with your health care team.

Other medicines—Do not take other medicines during the time you are taking insulin lispro unless they have been discussed with your doctor. This especially includes nonprescription medicines such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems.

Counseling—Other family members need to learn how to prevent side effects or help with side effects if they occur. Also, patients with diabetes may need special counseling about diabetes medicine dosing changes that might occur because of lifestyle changes, such as changes in exercise and diet. Furthermore, counseling on contraception and pregnancy may be needed because of the problems that can occur in patients with diabetes during pregnancy.

Travel—Keep a recent prescription and your medical history with you. Be prepared for an emergency as you would normally. Make allowances for changing time zones and keep your meal times as close as possible to your usual meal times.

In case of emergency—There may be a time when you need emergency help for a problem caused by your diabetes. You need to be prepared for these emergencies. It is a good idea to:

Wear a medical identification (ID) bracelet or neck chain at all times. Also, carry an ID card in your wallet or purse that says that you have diabetes and a list of all of your medicines.

Keep an extra supply of insulin lispro and syringes with needles or injection devices on hand in case high blood sugar occurs.

Keep some kind of quick-acting sugar handy to treat low blood sugar.

Have a glucagon kit and a syringe and needle available in case severe low blood sugar occurs. Check and replace any expired kits regularly.

insulin lispro, recombinant may cause a serious allergic reaction, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash; itching; shortness of breath; swelling of the face, tongue, and throat; trouble with breathing; or chest pain after you receive the medicine.

You may have some skin redness, rash, itching, or swelling at the injection site. If this irritation is severe or does not go away, call your doctor. Do not inject insulin lispro into a skin area that is red, swollen, or itchy.

Too much insulin lispro can cause hypoglycemia (low blood sugar). Low blood sugar also can occur if you use insulin lispro with another antidiabetic medicine, delay or miss a meal or snack, exercise more than usual, drink alcohol, or cannot eat because of nausea or vomiting or have diarrhea. Symptoms of low blood sugar must be treated before they lead to unconsciousness (passing out). Different people may feel different symptoms of low blood sugar. It is important that you learn which symptoms of low blood sugar you usually have so that you can treat it quickly.

Symptoms of low blood sugar include anxiety; behavior change similar to being drunk; blurred vision; cold sweats; confusion; depression; difficulty in thinking; dizziness or lightheadedness; drowsiness; excessive hunger; fast heartbeat; headache; irritability or abnormal behavior; nervousness; nightmares; restless sleep; shakiness; slurred speech; and tingling in the hands, feet, lips, or tongue.

If symptoms of low blood sugar occur, eat glucose tablets or gel, corn syrup, honey, or sugar cubes; or drink fruit juice, non-diet soft drink, or sugar dissolved in water to relieve the symptoms. Also, check your blood for low blood sugar. Get to a doctor or a hospital right away if the symptoms do not improve. Someone should call for emergency help immediately if severe symptoms such as convulsions (seizures) or unconsciousness occur. Have a glucagon kit available, along with a syringe and needle, and know how to use it. Members of your household also should know how to use it.

Hyperglycemia (high blood sugar) may occur if you do not take enough or skip a dose of your antidiabetic medicine or insulin, you overeat or do not follow your meal plan, have a fever or infection, or do not exercise as much as usual.

Symptoms of high blood sugar include blurred vision; drowsiness; dry mouth; flushed, dry skin; fruit-like breath odor; increased urination; ketones in the urine; loss of appetite; stomachache; nausea or vomiting; tiredness; troubled breathing (rapid and deep); unconsciousness; and unusual thirst.

If symptoms of high blood sugar occur, check your blood sugar level and then call your doctor for instructions.

insulin lispro, recombinant Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Anxious feeling

behavior change similar to being drunk

blurred vision

cold sweats

confusion

convulsions (seizures)

cough or hoarseness

depression

difficulty with thinking

dizziness or lightheadedness

drowsiness

excessive hunger

fast heartbeat

fever or chills

headache

irritability or abnormal behavior

lower back or side pain

nervousness

nightmares

painful or difficult urination

restless sleep

shakiness

slurred speech

tingling in the hands, feet, lips, or tongue

unconsciousness

Less common

Dry, red, hot, or irritated skin

Less common or rare

Depression of the skin at place of injection

dryness of the mouth

fast or weak pulse

increased thirst

irregular heartbeat

itching, redness, or swelling at the injection site

mood or mental changes

muscle cramps or pain

nausea or vomiting

shortness of breath

skin rash or itching over the whole body

sweating

thickening of the skin at the injection site

unusual tiredness or weakness

wheezing

Incidence not known

Bloating or swelling of the face, arms, hands, lower legs, or feet

decreased urine

difficult or labored breathing

difficulty with swallowing

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

fast, pounding, or irregular heartbeat or pulse

hives

increased sweating

itching

pain

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rapid weight gain

redistribution or accumulation of body fat

tightness in the chest

unusual weight gain or loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Body aches or pain

congestion

runny nose

sneezing

stuffy nose

tender, swollen glands in the neck

voice changes

Incidence not known

Redness, swelling, or itching at the injection site

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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More insulin lispro, recombinant Subcutaneous resources

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Diabetes, Type 1
Diabetes, Type 2

Iodex Topical

Generic Name: iodine (Topical route)

EYE-oh-dine

Commonly used brand name(s)

In the U.S.

Aplicare One Tincture Of Iodine

Iodex

Iodoflex

Iodosorb

Available Dosage Forms:

Swab

Ointment

Tincture

Dressing

Gel/Jelly

Therapeutic Class: Antibacterial

Uses For Iodex

Topical iodine is used to prevent and treat infections that may occur in minor scrapes and cuts. It works by killing bacteria that can cause infections.

Before Using Iodex

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Use of topical iodine is not recommended for newborn infants because it may cause skin and thyroid problems.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of topical iodine in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.

Interactions with Medicines

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of iodine

This section provides information on the proper use of a number of products that contain iodine. It may not be specific to Iodex. Please read with care.

Use this medicine only as directed.

This medicine is for external use only. Do not swallow it.

Keep this medicine away from the eyes because it may cause irritation. If you should accidentally get some in your eyes, wash it away with water immediately.

Do not use topical iodine on deep, puncture wounds, animal bites, or serious burns. To do so may increase the chance of side effects.

Do not cover the wound to which you have applied topical iodine with a tight dressing or bandage since this may increase the chance of side effects.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

For topical dosage form (tincture):
- For minor bacterial skin infections:
  - Adults and children 1 month of age and over—Use when necessary, according to the directions on the label or your doctor's instructions. Do not use for more than ten days.
  - Infants and children under 1 month of age—Use is not recommended.

To help clear up your infection completely, it is very important that you keep using topical iodine for the full time of treatment. Do not miss any doses.

Missed Dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Iodex

Check with your doctor if the skin problem for which you are using topical iodine becomes worse, or if you develop a constant irritation such as itching or burning that was not present before you started using this medicine.

This medicine can stain your skin and clothing. Alcohol may be used to remove iodine stain on the skin. Stains on clothing can be removed by washing and rinsing them in ammonia diluted with water. Stains on starched linens can be removed by washing them in soap and water.

Iodex Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Rare

Blistering, crusting, irritation, itching, or reddening of skin

Symptoms of overdose (when swallowed)

Abdominal or stomach pain

diarrhea

fever

nausea

not being able to pass urine

thirst, severe

vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Wednesday, October 26, 2016

Istalol

Generic Name: timolol (Ophthalmic route)

TIM-oh-lol

Commonly used brand name(s)

In the U.S.

Betimol

Istalol

Timoptic Ocudose

Timoptic Ocumeter

Timoptic Ocumeter Plus

Timoptic-XE Ocumeter

Timoptic-XE Ocumeter Plus

Available Dosage Forms:

Solution

Gel Forming Solution

Therapeutic Class: Antiglaucoma

Pharmacologic Class: Beta-Adrenergic Blocker, Nonselective

Uses For Istalol

Timolol is used alone or together with other medicines to treat increased pressure in the eye that is caused by open-angle glaucoma or a condition called ocular (eye) hypertension. This medicine is a beta-blocker .

This medicine is available only with your doctor's prescription .

Before Using Istalol

Allergies

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of timolol in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of timolol in the elderly .

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Albuterol

Amiodarone

Arformoterol

Bambuterol

Bitolterol

Broxaterol

Clenbuterol

Clonidine

Colterol

Diltiazem

Dronedarone

Epinephrine

Fenoldopam

Fenoterol

Formoterol

Hexoprenaline

Indacaterol

Isoetharine

Levalbuterol

Metaproterenol

Pirbuterol

Procaterol

Reproterol

Rimiterol

Ritodrine

Salmeterol

Terbutaline

Timolol

Tretoquinol

Tulobuterol

Verapamil

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acarbose

Aceclofenac

Acemetacin

Acetohexamide

Alclofenac

Alfuzosin

Amlodipine

Apazone

Arbutamine

Benfluorex

Benoxaprofen

Bromfenac

Bufexamac

Bunazosin

Carprofen

Chlorpropamide

Cimetidine

Clometacin

Clonixin

Dexketoprofen

Diclofenac

Diflunisal

Digoxin

Dipyrone

Doxazosin

Droxicam

Etodolac

Etofenamate

Felbinac

Felodipine

Fenbufen

Fenoprofen

Fentiazac

Floctafenine

Flufenamic Acid

Flurbiprofen

Gliclazide

Glimepiride

Glipizide

Gliquidone

Glyburide

Guar Gum

Ibuprofen

Indomethacin

Indoprofen

Insulin

Insulin Aspart, Recombinant

Insulin Glulisine

Insulin Lispro, Recombinant

Isoxicam

Ketoprofen

Ketorolac

Lacidipine

Lercanidipine

Lornoxicam

Manidipine

Meclofenamate

Mefenamic Acid

Meloxicam

Metformin

Methyldopa

Mibefradil

Miglitol

Moxisylyte

Nabumetone

Naproxen

Nicardipine

Nifedipine

Niflumic Acid

Nilvadipine

Nimesulide

Nimodipine

Nisoldipine

Nitrendipine

Oxaprozin

Oxyphenbutazone

Phenoxybenzamine

Phentolamine

Phenylbutazone

Pirazolac

Piroxicam

Pirprofen

Pranidipine

Prazosin

Propyphenazone

Proquazone

Quinidine

Repaglinide

St John's Wort

Sulindac

Suprofen

Tamsulosin

Tenidap

Tenoxicam

Terazosin

Tiaprofenic Acid

Tolazamide

Tolbutamide

Tolmetin

Trimazosin

Troglitazone

Urapidil

Zomepirac

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of timolol

This section provides information on the proper use of a number of products that contain timolol. It may not be specific to Istalol. Please read with care.

Shake the regular eye drops well just before each use. If you are using the gel-forming eye drops, turn the bottle upside down and shake it once. You do not need to shake the gel-forming eye drops more than once .

To use the eye drops (solution and gel):

First, wash your hands. Tilt the head back and, pressing your finger gently on the skin just beneath the lower eyelid, pull the lower eyelid away from the eye to make a space. Drop the medicine into this space. Let go of the eyelid and gently close the eyes. Do not blink. Keep the eyes closed and apply pressure to the inner corner of the eye with your finger for 1 or 2 minutes to allow the medicine to be absorbed by the eye.

Immediately after using the medicine, wash your hands to remove any medicine that may be on them.

To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye). Also, keep the container tightly closed. Serious damage to the eye and possible loss of vision may result from using contaminated eye medicines .

If your doctor ordered two different eye medicines to be used together, wait at least 10 minutes after the regular eye drops before using the second medicine. This will help prevent the second medicine from “washing out” the first one. The gel-forming eye drops should always be the last medicine used if two medicines are ordered. Wait 10 minutes before using the gel-forming eye drops .

You should not use the regular eye drops if you have contact lenses in your eyes. Remove your contact lenses before you use this medicine. Wait at least 15 minutes after you use the medicine before putting the contact lenses back in .

Dosing

For glaucoma or ocular hypertension:
- For ophthalmic gel-forming solution dosage form (eye drops):
  - Adults—One drop in the affected eye(s) once a day.
  - Children—Use and dose must be determined by your doctor .
- For ophthalmic solution dosage form (eye drops):
  - Adults—One drop in the affected eye(s) two times a day.
  - Children—Use and dose must be determined by your doctor .

Missed Dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Istalol

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects .

If itching, redness, swelling, or other signs of eye or eyelid irritation occur, stop using this medicine and check with your doctor. These signs may mean that you are allergic to this medicine .

Timolol may cause heart failure in some patients. Check with your doctor right away if you are having chest pain or discomfort; dilated neck veins; extreme fatigue; irregular breathing; an irregular heartbeat; shortness of breath; swelling of the face, fingers, feet, or lower legs; weight gain; or wheezing .

This medicine may cause changes in your blood sugar levels. Also, this medicine may cover up signs of low blood sugar, such as a rapid pulse rate. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests .

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery .

The gel-forming eye drops may cause blurred vision or other vision problems that last about 30 seconds to 5 minutes after you put them in your eye. If any of these occur, do not drive, use machines, or do anything else that could be dangerous if you are not able to see well. If these eye changes are bothersome, check with your doctor .

Istalol Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Blurred vision

burning or stinging in eye

Less common

Arm, back, or jaw pain

blisters, hives, welts, or itching

blue lips, fingernails, or skin

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

change in vision

chest pain or discomfort

chest tightness or heaviness

confusion about identity, place, and time

continuing ringing or buzzing or other unexplained noise in ears

coughing that sometimes produces a pink frothy sputum

depression

difficult, fast, noisy breathing, sometimes with wheezing

difficulty in chewing, swallowing, or talking

dilated neck veins

discharge, excessive tearing

disturbed color perception

dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly

double vision

drooping eyelids

dry or itching eyes

extreme fatigue

false sense of well-being

fast, slow, irregular, pounding, or racing heartbeat or pulse

fear, nervousness

feeling of having something in the eye

fever and chills

flashes of light, floaters in vision

general feeling of discomfort or illness

hair loss

halos around lights

headaches

inability to speak

increased sweating

irregular, fast or slow, or shallow breathing

large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

lightheadedness, dizziness, or fainting

loss of vision

memory loss

mood swings

muscle or joint pain

muscle weakness

nausea

night blindness

no blood pressure or pulse

overbright appearance of lights

pain, tension, and weakness upon walking that subsides during periods of rest

pale skin

paleness or cold feeling in fingertips, toes, hands, and feet

personality changes

pounding in the ears

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

redness of skin

redness, pain, swelling or irritation of eye, eyelid, or inner lining of eyelid

seeing double

seeing, hearing, or feeling things that are not there

seizures

severe numbness, especially on one side of the face or body

severe or sudden headache

severe tiredness

shortness of breath or troubled breathing

skin irritation or rash, including rash that looks like psoriasis

slurred speech

sore throat

stopping of heart

sweating

swelling of face, fingers, feet, lower legs, and ankles

swollen glands

temporary blindness

tingling or pain in fingers or toes when exposed to cold

tunnel vision

unconsciousness

unusual tiredness or weakness

weakness in arm and/or leg on one side of the body, sudden and severe

weight gain

wheezing

Less common

Acid or sour stomach

belching

body aches or pain

diarrhea

dry mouth

ear congestion

hearing loss

heartburn

indigestion

lack or loss of strength

loss of appetite

loss of voice

nightmares

runny nose

sleepiness or unusual drowsiness

sleeplessness

sneezing

stomach discomfort, upset, or pain

stuffy nose

trouble sleeping

unable to sleep

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Istalol side effects (in more detail)

More Istalol resources

Istalol Side Effects (in more detail)
Istalol Use in Pregnancy & Breastfeeding
Istalol Drug Interactions
Istalol Support Group
0 Reviews for Istalol - Add your own review/rating

Istalol Prescribing Information (FDA)

Istalol Consumer Overview

Istalol Drops MedFacts Consumer Leaflet (Wolters Kluwer)

Timolol Ophthalmic Prescribing Information (FDA)

Betimol Drops MedFacts Consumer Leaflet (Wolters Kluwer)

Betimol Prescribing Information (FDA)

Compare Istalol with other medications

Glaucoma, Open Angle
Intraocular Hypertension

interferon alfa-2a

Generic Name: interferon alfa-2a ( in ter FEAR on AL fa 2 A)

Brand Names: Roferon-A

What is interferon alfa-2a?

Interferon alfa-2a is a protein. Interferons are released in the body in response to viral infections. Interferons are important for fighting viruses in the body, regulating reproduction of cells, and regulating the immune system.

Interferon alfa-2a is used to treat chronic hepatitis C, hairy cell leukemia, AIDS-related Kaposi's sarcoma, and some types of chronic myelogenous leukemia (CML).

Interferon alfa-2a may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about interferon alfa-2a?

Call your doctor or seek emergency medical attention if you develop symptoms of depression or are contemplating suicide; become unusually irritable, anxious (nervous), or aggressive; or experience other mood or behavior changes. In some cases, interferon alfa-2a has caused serious mood or behavioral problems. Problems with body organs such as the heart, lungs, and eyes have been experienced by people taking interferon alfa-2a or other similar drugs. Contact your doctor immediately if you develop difficulty breathing, chest pain, blurred vision, or loss of vision.

Some patients taking interferon alfa-2a have developed a drop in the number of white blood cells and platelets. If the number of these blood cells are too low, there is an increased risk of infection or bleeding. Contact your doctor immediately if you develop a fever, symptoms of an infection, or unusual bleeding or bruising.

Use caution when driving, operating machinery, or performing other hazardous activities. Interferon alfa-2a may cause drowsiness, dizziness, or impaired alertness. If you experience drowsiness, dizziness, or impaired alertness, avoid these activities.

What should I discuss with my healthcare provider before using interferon alfa-2a?

Do not use interferon alfa -2a without first talking to your doctor if you have had an allergic reaction to an alfa interferon in the past or if you are allergic to E. coli derived products. Also, do not use interferon alfa-2a if you have an allergy to the preservative benzyl alcohol.

Before using interferon alfa-2a, talk to your doctor if you

a history of depression, suicidal thoughts, anxiety, drug or alcohol abuse, or another mental illness;

an active infection;

heart disease or history of a heart attack;

an autoimmune disorder such as rheumatoid arthritis, systemic lupus erythematosus (SLE), or psoriasis;

have a suppressed immune system or have received an organ transplant,

have a seizure disorder,

have diabetes,

have bone marrow suppression,

have kidney disease, or

have liver disease.

You may not be able to use interferon alfa-2a, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Interferon alfa-2a is in the FDA pregnancy category C. This means that it is not known whether interferon alfa-2a will be harmful to an unborn baby. Do not use this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether interferon alfa-2a passes into breast milk. Do not use this medication without first talking to your doctor if you are breast-feeding.

How should I use interferon alfa-2a?

Use interferon alfa-2a exactly as directed by your doctor. If you do not understand these directions, ask your doctor, nurse, or pharmacist to explain them to you.

Interferon alfa-2a is used as an intramuscular or subcutaneous injection only. Your doctor or nurse will give you detailed instructions on how and where to inject this medication. Do not inject this medication if you are unsure how.

Drink 6 to 8 full glasses of water daily to ensure adequate hydration, especially at the start of treatment.

Flulike symptoms are likely to occur. They are most common at the start of therapy and may decrease with continued use. Over-the-counter fever reducers such as acetaminophen (Tylenol, others), ibuprofen (Motrin, Advil, others), and naproxen (Aleve), plenty of fluid, and taking the medication at bedtime may help to alleviate these symptoms.

Do not inject interferon alfa-2a if it is discolored or has particles in it.

Do not change the brand or generic formulation of interferon alfa-2a that you are using without first talking to your doctor or pharmacist. Some brands of interferon alfa-2a are interchangeable while others are not. Your doctor and/or pharmacist know which brand/generic formulations may be substituted for another.

Do not shake the vial of interferon alfa-2a. If mixing is required, the vial should be gently swirled.

If the interferon alfa-2a you are using is preservative-free, use only one dose from each vial. Throw away any medicine that is not used with the first dose, do not save it for later use

Never reuse a needle or syringe. Dispose of all needles and syringes in an appropriate, puncture-resistant disposal container.

Your doctor may want you to have blood tests performed before and periodically during treatment with an interferon alfa-2a.

It is not known whether treatment with alfa interferon will prevent the transmission of hepatitis to others. It is also not known whether alfa interferons will cure hepatitis or prevent cirrhosis, liver failure, or liver cancer that may be the result of infection with a hepatitis virus.

Do not stop using this medication without first talking to your doctor. Store interferon alfa-2a in the refrigerator between 36 and 46 degrees Fahrenheit (2 and 8 degrees Celsius). Do not allow interferon alfa-2a to freeze. The Roferon-A multidose vials of injectable solution should be used within 30 days after the first dose is taken from the vial.

What happens if I miss a dose?

Use the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed and use only the next regularly scheduled dose. Do not use a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention if an overdose is suspected.

Symptoms of interferon alfa-2a overdose are not well known but may include decreased appetite, chills, fever, and muscle aches.

What should I avoid while using interferon alfa-2a?

Interferon alfa-2a side effects

If you experience an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives), stop using interferon alfa-2a and seek emergency medical attention.

Flu-like symptoms are likely to occur. They are most common at the start of therapy and may decrease with continued use. Over-the-counter fever reducers such as acetaminophen (Tylenol, others), ibuprofen (Motrin, Advil, others), and naproxen (Aleve), plenty of fluids, and taking the medication at bedtime may help to alleviate these symptoms. Continue to use interferon alfa-2a and notify your doctor if you experience

fever or chills;

fatigue;

headache;

muscle aches or sore joints;

numbness or tingling;

nausea, vomiting, or loss of appetite;

diarrhea;

dizziness or drowsiness;

nervousness or anxiety;

insomnia;

loss or thinning of hair;

increased sweating;

itching or a rash; or

pain, redness, or bruising at the injection site.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Interferon alfa-2a Dosing Information

Usual Adult Dose for Chronic Hepatitis C:

3 million intl units subcutaneously or IM three times a week for 48 to 52 weeks (12 months). Alternatively 6 million intl units three times a week for the first 12 weeks (3 months), followed by 3 million intl units three times a week for 36 weeks (9 months).

Usual Adult Dose for Chronic Myelogenous Leukemia:

9 million intl units daily subcutaneously or IM.

Usual Adult Dose for Hairy Cell Leukemia:

Induction dose: 3 million intl units daily subcutaneously or IM for 16 to 24 weeks.
Maintenance dose: 3 million intl units three times a week for up to 24 consecutive months.

Usual Adult Dose for Kaposi's Sarcoma:

Induction dose: 36 million intl units daily subcutaneously or IM for 10 to 12 weeks.
Maintenance dose: 36 million intl units three times a week.

Usual Adult Dose for Lymphoma:

Study (n=5) - Lymphomatoid Papulosis
3 to 15 million intl units three times per week subcutaneously for up to 13 months.

Usual Adult Dose for Renal Cell Carcinoma:

Study (n=75) Metastatic Renal-Cell Carcinoma
subcutaneous injection three times weekly, 4.5 million units titrated upwards to 18 million units, as tolerated, during the first 4 weeks (weekly dose increases). The individual maintenance dose, based on tolerability of side effects, was continued for 3 weeks (out of a 4-week cycle), up to 2 years if the patient responds or has stable disease.

Usual Pediatric Dose for Chronic Myelogenous Leukemia:

Study (n=15)
2.5 to 5 million intl units/m2/day IM

Study (n=12) Philadelphia Chromosome-Positive CML
5 million intl units/m2/day subcutaneously (combined with Cytarabine 20 mg/m2/day for 10 days monthly).

What other drugs will affect interferon alfa-2a?

Before using interferon alfa-2a, tell your doctor if you are taking theophylline (Theo-Dur, Theochron, Theolair, others). Interferon alfa-2a may increase theophylline levels in the body, which could become dangerous.

Other drugs may also interact with interferon alfa-2a. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

More interferon alfa-2a resources

Interferon alfa-2a Side Effects (in more detail)
Interferon alfa-2a Use in Pregnancy & Breastfeeding
Interferon alfa-2a Drug Interactions
Interferon alfa-2a Support Group
0 Reviews for Interferon alfa-2a - Add your own review/rating

interferon alfa-2a Subcutaneous Advanced Consumer (Micromedex) - Includes Dosage Information

Interferon Alfa-2a Solution MedFacts Consumer Leaflet (Wolters Kluwer)

Interferon Alfa-2a Professional Patient Advice (Wolters Kluwer)

Roferon-A Prescribing Information (FDA)

Compare interferon alfa-2a with other medications

Chronic Myelogenous Leukemia
Hairy Cell Leukemia
Hepatitis C
Kaposi's Sarcoma
Lymphoma
Renal Cell Carcinoma

Where can I get more information?

Your pharmacist has additional information about interferon alfa-2a written for health professionals that you may read.

What does my medication look like?

Interferon alfa-2a is available with a prescription under the brand name Roferon-A. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

See also: interferon alfa-2a side effects (in more detail)

Thursday, October 27, 2016

Iprivask

What is Iprivask (desirudin)?

What is the most important information I should know about Iprivask (desirudin)?

What should I discuss with my healthcare provider before using Iprivask (desirudin)?

How should I use Iprivask (desirudin)?

What happens if I miss a dose?

What happens if I overdose?

What should I avoid while using Iprivask (desirudin)?

Iprivask (desirudin) side effects

What other drugs will affect Iprivask (desirudin)?

More Iprivask resources

Compare Iprivask with other medications

Where can I get more information?

What does my medication look like?

Imitrex Tablets

Imitrex is used for:

Do NOT use Imitrex if:

Before using Imitrex:

How to use Imitrex:

Important safety information:

Possible side effects of Imitrex:

If OVERDOSE is suspected:

General information:

More Imitrex resources

Compare Imitrex with other medications

Insulin Isophane (NPH)/Insulin Regular Pens

Insulin Isophane (NPH)/Insulin Regular Pens are used for:

Do NOT use Insulin Isophane (NPH)/Insulin Regular Pens if:

Before using Insulin Isophane (NPH)/Insulin Regular Pens:

How to use Insulin Isophane (NPH)/Insulin Regular Pens:

Important safety information:

Possible side effects of Insulin Isophane (NPH)/Insulin Regular Pens:

If OVERDOSE is suspected:

General information:

More Insulin Isophane (NPH)/Insulin Regular resources

Compare Insulin Isophane (NPH)/Insulin Regular with other medications

insulin lispro, recombinant Subcutaneous

Commonly used brand name(s)

Uses For insulin lispro, recombinant

Before Using insulin lispro, recombinant

Allergies

Pediatric

Geriatric

Pregnancy

Breast Feeding

Interactions with Medicines

Interactions with Food/Tobacco/Alcohol

Other Medical Problems

Proper Use of insulin lispro, recombinant

Dosing

Missed Dose

Storage

Precautions While Using insulin lispro, recombinant

insulin lispro, recombinant Side Effects

More insulin lispro, recombinant Subcutaneous resources

Compare insulin lispro, recombinant Subcutaneous with other medications

Iodex Topical

Commonly used brand name(s)

Uses For Iodex

Before Using Iodex

Allergies

Pediatric

Geriatric

Interactions with Medicines

Interactions with Food/Tobacco/Alcohol

Other Medical Problems

Proper Use of iodine

Dosing

Missed Dose

Storage

Precautions While Using Iodex

Iodex Side Effects

More Iodex Topical resources

Wednesday, October 26, 2016

Istalol

Commonly used brand name(s)

Uses For Istalol

Before Using Istalol

Allergies